化学生物学
胰岛素
圣杯
计算生物学
纳米技术
化学
生物
计算机科学
生物技术
生物化学
材料科学
万维网
作者
Yanxian Zhang,Danny Hung‐Chieh Chou
标识
DOI:10.1002/cbic.202300470
摘要
Abstract Since its discovery in 1921, insulin has been at the forefront of scientific breakthroughs. From its amino acid sequencing to the revelation of its three‐dimensional structure, the progress in insulin research has spurred significant therapeutic breakthroughs. In recent years, protein engineering has introduced innovative chemical and enzymatic methods for insulin modification, fostering the development of therapeutics with tailored pharmacological profiles. Alongside these advances, the quest for self‐regulated, glucose‐responsive insulin remains a holy grail in the field. In this article, we highlight the pivotal role of chemical biology in driving these innovations and discuss how it continues to shape the future trajectory of insulin research.
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