极性（国际关系）
巨噬细胞
肿瘤微环境
癌症
生物
癌症研究
细胞
医学
肿瘤细胞
内科学
遗传学
体外
作者
Ruben Bill,Pratyaksha Wirapati,Marius Messemaker,Whijae Roh,Béatrice Zitti,Florent Duval,Máté Kiss,Jong Chul Park,Talia M. Saal,Jan Hoelzl,David Tarussio,Fabrizio Benedetti,Stéphanie Tissot,Lana E. Kandalaft,Marco Varrone,Giovanni Ciriello,Thomas McKee,Yan Monnier,Maxime Mermod,Emily M. Blaum
出处
期刊：Science
[American Association for the Advancement of Science]
日期：2023-08-03
卷期号：381 (6657): 515-524
被引量：236
标识
DOI：10.1126/science.ade2292
摘要
Tumor microenvironments (TMEs) influence cancer progression but are complex and often differ between patients. Considering that microenvironment variations may reveal rules governing intratumoral cellular programs and disease outcome, we focused on tumor-to-tumor variation to examine 52 head and neck squamous cell carcinomas. We found that macrophage polarity-defined by
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