SIRT7 facilitates ferroptosis resistance of melanocytes via activating the SMAD3-ATF3-GPX4 signaling pathway in vitiligo

Our study demonstrates that SIRT7 deficiency exacerbated ferroptosis of melanocytes induced by oxidative stress and contributed to vitiligo pathogenesis. The activation of SIRT7 could serve as a potential therapeutic strategy for preserving melanocyte survival in vitiligo.