Dynamic multistage hydrogel with auto-adjusting networks for sequential anti-infection, anti-inflammation, and angiogenesis in infected wound regeneration

and SCS, which fosters angiogenesis and sustains tissue regeneration. Experimental results confirm that this hydrogel effectively combats bacterial infection and mitigates excessive ROS during the inflammatory phase, subsequently enhancing angiogenesis to stimulate cell proliferation and tissue reconstruction. By offering a sequential, stage-specific therapeutic strategy, the FSCP hydrogel represents a novel and versatile platform for the treatment of bacterial-infected wounds, meeting the diverse and evolving needs of wound healing in clinical settings.