Photodynamic-Photothermal Switching in Osmium-Ferritin Nanoplatform Activates Near Infrared-Driven Tumor Immunity Reprogramming

NPs for bioimaging and metabolic tracking while also demonstrating significant tumor growth inhibition and enhanced immune cell infiltration. In conclusion, this study reports an intelligent phototheranostic system whose functional modality adaptively shifts in response to molecular aggregation-dispersion states. This spatiotemporally regulated immunometabolic activation establishes a linkage between multimechanistic synergy and combinatorial immunotherapy.