Jiedu Huayu suppress ferroptosis induced by 5-lipoxygenase-dependent peroxidation in acute liver failure

JDHY suppresses 5-LOX-catalyzed lipid peroxidation via negative feedback regulation of the cAMP-PKA pathway, mitigating ALF-associated ferroptosis. Moreover, the data provided in this paper suggest that 5-LOX can serve as a potential target for inhibiting ALF ferroptosis, providing a scientific basis for the clinical prevention and treatment of ALF.