CD47-SIRPα: A Pivotal Signaling Pathway for Targeting Immunotherapy in Non-Small Cell Lung Cancer

Abstract: Non-Small Cell Lung Cancer (NSCLC) remains a major oncologic challenge with high mortality. The CD47-SIRPα pathway is critical for tumor immune escape by mediating “don't eat me” signaling. Despite progress, the specific mechanism of action of this pathway in NSCLC remains unclear, and the specific role of the CD47-signal in regulating immune escape needs to be further explored. This paper comprehensively analyzes the latest research progress on the CD47-SIRPα signaling pathway in NSCLC, as well as the challenges of CD47-SIRPα as a potential therapeutic target.