Meta-analysis of Transcatheter Edge-to-Edge Repair for Atrial Functional Mitral Regurgitation

Atrial functional mitral regurgitation (aFMR) represents a subtype of secondary mitral regurgitation (MR) closely associated with left atrial (LA) enlargement and mitral annular dilation in the setting of preserved left ventricular ejection fraction (LVEF), absence of primary mitral valve pathology, and commonly, presence of atrial fibrillation (AF).1-3 However, there is no consensus on a unified definition of aFMR. Published studies had different cutoffs for LVEF, LA volume index, and left ventricular dimensions.