内大麻素系统
化学
癌症研究
酶
脂肪酶
激活剂(遗传学)
二酰甘油激酶
生物化学
内科学
医学
受体
基因
蛋白激酶C
作者
Mingjian Ma,Guangyan Zeng,Bien‐Keem Tan,Guochao Zhao,Shan Qiao,Wenhui Zhang,Yee Jiun Song,Jiahua Liang,Borui Xu,Zicheng Wang,Jiancong Chen,Mengjun Hou,Jinbao Liu,Jing‐Ping Yun,Yuhua Huang,Yansong Lin,Demeng Chen,Yuyan Han,Sharon DeMorrow,Liang Liu,Jiaming Lai,Li Huang
出处
期刊:American Journal of Physiology-gastrointestinal and Liver Physiology
[American Physiological Society]
日期:2023-09-01
卷期号:325 (3): G213-G229
标识
DOI:10.1152/ajpgi.00243.2022
摘要
Dysregulated endocannabinoid system (ECS) had been confirmed in various liver diseases. However, regulation and function of 2-arachidonoyl glycerol (2-AG) and diacylglycerol lipase β (DAGLβ) in intrahepatic cholangiocarcinoma (ICC) remain to be elucidated. Here, we demonstrated that 2-AG was enriched in ICC, and DAGLβ was the principal synthesizing enzyme of 2-AG in ICC. DAGLβ promotes tumorigenesis and metastasis in ICC via a novel activator protein-1 (AP-1)/DAGLβ/miR4516 feedforward circuitry.
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