失调
殖民抵抗
肺炎克雷伯菌
生物
肠道菌群
殖民地化
微生物学
肠杆菌科
病菌
免疫学
大肠杆菌
遗传学
基因
作者
Aaron L. Hecht,Lisa Harling,Elliot S. Friedman,Ceylan Tanes,Junhee Lee,Jenni Firrman,Vincent Tu,LinShu Liu,Kyle Bittinger,Mark Goulian,Gary D. Wu
标识
DOI:10.1101/2023.05.25.542283
摘要
Dysbiosis of the gut microbiota is increasingly appreciated as both a consequence and precipitant of human disease. The outgrowth of the bacterial family Enterobacteriaceae is a common feature of dysbiosis, including the human pathogen Klebsiella pneumoniae . Dietary interventions have proven efficacious in the resolution of dysbiosis, though the specific dietary components involved remain poorly defined. Based on a previous human diet study, we hypothesized that dietary nutrients serve as a key resource for the growth of bacteria found in dysbiosis. Through human sample testing, and ex-vivo , and in vivo modeling, we find that nitrogen is not a limiting resource for the growth of Enterobacteriaceae in the gut, contrary to previous studies. Instead, we identify dietary simple carbohydrates as critical in colonization of K. pneumoniae . We additionally find that dietary fiber is necessary for colonization resistance against K. pneumoniae , mediated by recovery of the commensal microbiota, and protecting the host against dissemination from the gut microbiota during colitis. Targeted dietary therapies based on these findings may offer a therapeutic strategy in susceptible patients with dysbiosis.
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