Screening for thrombophilia in patients with thromboangitis obliterans using whole-exome sequencing

The aetiology of Thromboangitis obliterans (TAO) is not well understood. There is disagreement on the inclusion of thrombophilia in a TAO diagnosis, and no internationally accepted diagnostic criteria have been established. Of the four main diagnostic criteria for TAO, Olin's criteria and Mills' criteria describe hypercoagulable states as exclusion criteria, but Shionoya's criteria and Papa's criteria do not [1]. Additionally, during the 2022 International Delphi Consensus, there was disagreement among experts on using thrombophilia as an exclusion criterion [1].