Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues

H, 1D-selective TOCSY and HSQC NMR, and developed a modular fragment-based synthesis of these compounds. By providing a unified methodology for genetic sensitivity profiling, precise structure and stereochemistry determination, and modular total synthesis, this work unlocks new opportunities for the discovery and rational design of potent marine-derived therapeutics.