p38丝裂原活化蛋白激酶
活性氧
肿瘤坏死因子α
细胞生物学
MAPK/ERK通路
肿瘤微环境
癌症研究
抗氧化剂
激酶
化学
材料科学
生物
免疫学
生物化学
肿瘤细胞
作者
Dongmei Yang,Minjia Yuan,Jianbo Huang,Xi Xiang,Houqing Pang,Qiang Wei,Xingguang Luο,Chong Cheng,Li Qiu,Lang Ma
出处
期刊:ACS Nano
[American Chemical Society]
日期:2024-01-16
标识
DOI:10.1021/acsnano.3c10552
摘要
Solar dermatitis, a form of acute radiation burn that affects the skin, results from overexposure to ultraviolet B (UVB) radiation in strong sunlight. Cell damage caused by the accumulation of reactive oxygen species (ROS) produced by UVB radiation plays an important role in UVB-induced inflammation in the skin. Here, for efficiently scavenging excess ROS, modulating the microenvironment, and alleviating solar dermatitis, a π-conjugated network polyphthalocyanine supporting a highly surface-exposed Ru active site-based artificial antioxidase (HSE-PPcRu) is designed and fabricated with excellent ROS-scavenging, antioxidant, and anti-inflammatory capabilities. In photodamaged human keratinocyte cells, HSE-PPcRu could modulate mitogen-activated protein kinase (MAPK) and nuclear factor kappa-B signaling pathways, prevent DNA damage, suppress apoptosis, inhibit pro-inflammatory cytokine secretion, and alleviate cell damage. In vivo animal experiments reveal the higher antioxidant and anti-inflammatory efficacies of HSE-PPcRu by reversing the activation of p38 and c-Jun N-terminal kinase, inhibiting expression of cyclooxygenase-2, interleukin-6, interleukin-8, and tumor necrosis factor-α. This work not only provides an idea for alleviating solar dermatitis via catalytically scavenging ROS and modulating the microenvironment but also offers a strategy to design an intelligent conjugated network-based artificial antioxidase with a highly surface-exposed active site.
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