镧系元素
血红素
化学
三磷酸腺苷
组合化学
壳聚糖
乳酸链球菌素
沸石咪唑盐骨架
激进的
催化作用
抗菌活性
纳米技术
生物化学
材料科学
细菌
抗菌剂
有机化学
血红素
金属有机骨架
酶
遗传学
吸附
生物
作者
Huihong Chen,Songzhe Fu,Xiaoqian Chen,Ruyi Chen,Hongliang Tan
出处
期刊:Small
[Wiley]
日期:2023-12-26
标识
DOI:10.1002/smll.202309403
摘要
Abstract Nanozymes have shown promise for antibacterial applications, but their effectiveness is often hindered by low catalytic performances in physiological conditions and uncontrolled production of hydroxyl radicals (·OH). To address these limitations, a comprehensive approach is presented through the development of an adenosine triphosphate (ATP)‐activated cascade reactor (GGPcs). The GGPcs reactor synergistically combines the distinct properties of zeolitic imidazolate framework‐8 (ZIF‐8) and chitosan‐integrated hydrogel microsphere. The ZIF‐8 allows for the encapsulation of G‐quadruplex/hemin DNAzyme to achieve ATP‐responsive ·OH generation at neutral pH, while the hydrogel microsphere creates a confinement environment that facilitates glucose oxidation and provides a sufficient supply of H 2 O 2 . Importantly, the integrated chitosan in the hydrogel microsphere shields ZIF‐8 from undesired disruption caused by gluconic acid, ensuring the responsive specificity of ZIF‐8 toward ATP. By activating GGPcs with ATP secreted by bacteria, its effectiveness as an antibacterial agent is demonstrated for the on‐demand treatment of bacterial infection with minimal side effects. This comprehensive approach has the potential to facilitate the design of advanced nanozyme systems and broaden their biological applications.
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