Persimmon Tannin-Reduction Graphene Oxide-Platinum-Palladium Nanocomposite Decorated on Screen-Printed Carbon Electrode for Enhanced Electrocatalytic Reduction of Hydrogen Peroxide

According to studies, Hydrogen peroxide (H 2 O 2 ) is a significant biomarker of physiological processes. Unnormal H 2 O 2 levels in human body may result in diseases. Hence, there is an increasing demand for monitoring the H 2 O 2 concentrations in biological specimen. Here, we construct a non-enzymatic H 2 O 2 electrochemical biosensor based on persimmon tannin-reduced graphene oxide-platinum-palladium nanocomposite (PrG-Pt@Pd NPs) modified with screen-printed carbon electrode (SPE). Combined with suitable electrocatalytic mode for Pt@Pd NPs, high specific large specific volume and good electrical conductivity of RGO, well as the superior sorption capacity of PT for metal-based nano-ion, the PrGPt@Pd striped pleasing heterogeneous catalytic activity toward H 2 O 2 reduction via the synergistic effect. In experimental conditions of optimal, this non-enzymatic electrochemical sensor exhibited excellent electrocatalytic performance for H 2 O 2 with less negative potential (−0.5 V), fast response time (<3 s), it shows good linearity in the range of 5.0–100.0 μ M, in addition to this LOD of this sensor was 0.059 μ M as well as the excellent sensitivity of the sensor (13.696 μ A· μ M −1 ·cm −2 ). Due to excellent specificity, lower detection limit, and good recovery (98.70–99.96%) in the spiked measurements of human serum samples, this non-enzymatic electrochemical biosensor paves the way for H 2 O 2 detection at ultra-low concentrations in physiology and diagnosis.