纳米探针
液体活检
转移
循环肿瘤细胞
癌症
生物标志物
癌症研究
肺癌
分子信标
癌细胞
结直肠癌
医学
病理
生物
内科学
基因
材料科学
寡核苷酸
纳米技术
生物化学
纳米颗粒
作者
Di Han,Xiaohe Ren,Xin‐Ru Liao,Xiaoyan He,Tao Guo,Xuesi Chen,Xuan Pang,Si‐Xue Cheng
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-04-13
卷期号:23 (9): 3678-3686
标识
DOI:10.1021/acs.nanolett.2c04643
摘要
Identification of cancer metastatic sites is of importance for adjusting therapeutic interventions and treatment choice. However, identifying the location of metastatic lesions with easy accessibility and high safety is challenging. Here we demonstrate that cancer metastatic sites can be accurately detected by a triple targeting nanoprobe. Through coencapsulating molecular beacons probing a cancer biomarker (CXCR4 mRNA), a lung metastatic biomarker (CTSC mRNA), and a bone metastatic biomarker (JAG1 mRNA), the nanoprobe decorated by SYL3C conjugated hyaluronic acid and ICAM-1 specific aptamer conjugated hyaluronic acid can target diverse phenotyped circulating tumor cells (CTCs) during epithelial-mesenchymal and mesenchymal-epithelial transitions in whole blood for sensitive probing. The detection of CTCs from cancer patients shows that the nanoprobe can provide accurate information to distinguish different cancer metastasis statuses including nonmetastasis, lung metastasis, and bone metastasis. This study proposes an efficient screening tool for identifying the location of distant metastatic lesions via facile blood biopsy.
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