Facile Synthesis of Copper‐5‐Aminoisophthalic Acid Metal Organic Framework as a Potential Drug Carrier for Ibuprofen

Due to their large surface area and porous nature, metal organic frameworks hold a promising application in drug delivery. Among several combinations of metals with organic linkers, copper as a metal possesses synergistic behavior in drug delivery due to its antibacterial, antioxidant properties, and other biological functional necessities. This study uses the copper-5-aminoisophthalic acid metal organic framework (AIPA-Cu (II) MOF) for drug delivery. From the experimental studies, AIPA-Cu (II) MOF exhibited a potentially good loading capacity of Ibuprofen drug and excellent controlled release in in-vitro drug release studies. The loading efficiency of Ibuprofen in AIPA-Cu (II) MOF has been confirmed using BET adsorption, X-Ray Diffraction, XPS spectroscopy, UV-Visible Spectroscopy, and IR spectroscopy by comparing it against unloaded AIPA-Cu (II) MOF. The uncoordinated free amino group in the 5-aminoisophthalic acid ligand is expected to form an interaction between Ibuprofen and AIPA-Cu (II) MOF through van der Waals force to induce better loading. Thus, the current study opens up a new avenue for the potential usage of AIPA-Cu (II) MOF as an effective and compatible drug carrier for hydrophobic drugs like Ibuprofen.