MP75-01 THE ASSOCIATION BETWEEN LOWER URINARY TRACT SYMPTOM SUBTYPES AND COGNITIVE IMPAIRMENT TESTING IN COMMUNITY DWELLING ADULTS: RESULTS FROM NHANES

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Non-neurogenic Voiding Dysfunction (Excluding OAB) (MP75)1 May 2024MP75-01 THE ASSOCIATION BETWEEN LOWER URINARY TRACT SYMPTOM SUBTYPES AND COGNITIVE IMPAIRMENT TESTING IN COMMUNITY DWELLING ADULTS: RESULTS FROM NHANES Rahul Dutta and Mary Ann Lynn Stothers Rahul DuttaRahul Dutta and Mary Ann Lynn StothersMary Ann Lynn Stothers View All Author Informationhttps://doi.org/10.1097/01.JU.0001008676.21744.5f.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Dementia has been associated with lower urinary tract symptoms (LUTS) in care-seeking populations. We examined the association between cognitive impairment (CI) in various domains based on objective validated cognitive assessment tools and LUTS in community-dwelling adults. METHODS: Subjects from the NHANES (National Health and Nutrition Examination Survey) from 2011-2014 over age 60 were included. They completed testing for different domains of CI: the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) with word learning (CERAD-WL) and delayed recall (CERAD-DL) subsections, the Animal Fluency test (AF), and the Digit Symbol Substitution test (DSST). Previously established cutoffs for CI of less than 17, 5, 14, and 34 points, respectively, were used. They also completed a survey of LUTS which included urinary incontinence (UI) with stress (SUI) or urge (UUI) and nocturia. RESULTS: A total of 3,126 participants (52% female, mean age 70) were included. Upon univariate analysis, subjects reporting SUI alone across each test were less likely to have CI (p<0.01 for all). UUI was associated with CI only on the DSST (p=0.01), while MUI was not associated with CI on any of the tests (p>0.05 for all). Nocturia was associated with CI on every test (p<0.01 for all). Multivariate logistic regression controlling for age and gender for likelihood of having SUI showed an independent association with not having CI across all tests (Odds ratio [OR] range 0.69 – 0.83 between the 4 tests, p<0.0001 for all). UUI was significantly associated with CI on the CERAD-DR (OR=1.18), AF (OR=1.18), and DSST (OR=1.36; p<0.0001 for all). MUI was significantly associated with CI on the CERAD-DR (OR=1.02), AF (OR=1.04), and DSST (OR=1.12; p<0.0001 for all). Nocturia was associated with CI on all tests (OR range 1.12 – 1.78, p<0.0001 for all). Although significant associations were found for UUI and MUI, they were not all in the same direction for each test of CI. CONCLUSIONS: Nocturia is associated with cognitive impairment independent of age and gender across multiple tests of cognition, while the opposite is true for stress urinary incontinence. Further study is warranted to establish pathophysiology and the direction of effect. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1231 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Rahul Dutta More articles by this author Mary Ann Lynn Stothers More articles by this author Expand All Advertisement PDF downloadLoading ...