降钙素基因相关肽
偏头痛
医学
降钙素
慢性偏头痛
单克隆抗体
遗传增强
发病机制
药理学
生物信息学
免疫学
内科学
神经肽
基因
受体
抗体
生物
遗传学
作者
Sawsan Alabbad,Nathalia Figueredo,Hsiangkuo Yuan,Stephen D Silberstein
标识
DOI:10.1080/14737175.2024.2332754
摘要
Introduction Calcitonin Gene-Related Peptide (CGRP)-targeted therapy has revolutionized migraine treatment since its first approval in 2018. CGRP-targeted therapy includes monoclonal antibodies (mAbs) and gepants, which modulate trigeminal nociceptive and inflammatory responses, alleviating pain sensitization involved in migraine pathogenesis. CGRP-targeted therapy is effective not only for migraine but also for other chronic headache disorders that share the CGRP pathway.
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