Copper(II)-Promoted Mono-Selective ortho C–H Chlorination of Arenes by Using Trimethyl(trichloromethyl)silane

The first example of a Cu-promoted ortho-chlorination of aryl C–H bonds by using TMSCCl3 as chlorinating agent is reported. This reaction features a high selectivity toward monochlorination over dichlorination, compatibility with a variety of functional groups, and gram-scale synthesis.