医学
乳腺癌
无线电技术
神经组阅片室
前哨淋巴结
放射科
转移
逻辑回归
磁共振弥散成像
活检
磁共振成像
癌症
内科学
神经学
精神科
作者
Yang Dong,Qianjin Feng,Wei Yang,Zixiao Lu,Chunyan Deng,Lu Zhang,Lian Zhou,Jing Liu,Xiaoning Luo,Shufang Pei,Xiaokai Mo,Wenhui Huang,Changhong Liang,Bin Zhou,Shuixing Zhang
标识
DOI:10.1007/s00330-017-5005-7
摘要
To predict sentinel lymph node (SLN) metastasis in breast cancer patients using radiomics based on T2-weighted fat suppression (T2-FS) and diffusion-weighted MRI (DWI). We enrolled 146 patients with histologically proven breast cancer. All underwent pretreatment T2-FS and DWI MRI scan. In all, 10,962 texture and four non-texture features were extracted for each patient. The 0.623 + bootstrap method and the area under the curve (AUC) were used to select the features. We constructed ten logistic regression models (orders of 1–10) based on different combination of image features using stepwise forward method. For T2-FS, model 10 with ten features yielded the highest AUC of 0.847 in the training set and 0.770 in the validation set. For DWI, model 8 with eight features reached the highest AUC of 0.847 in the training set and 0.787 in the validation set. For joint T2-FS and DWI, model 10 with ten features yielded an AUC of 0.863 in the training set and 0.805 in the validation set. Full utilisation of breast cancer-specific textural features extracted from anatomical and functional MRI images improves the performance of radiomics in predicting SLN metastasis, providing a non-invasive approach in clinical practice. • SLN biopsy to access breast cancer metastasis has multiple complications.
• Radiomics uses features extracted from medical images to characterise intratumour heterogeneity.
• We combined T
2
-FS and DWI textural features to predict SLN metastasis non-invasively.
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