Cooperative Activation Modes for Catalysis-Based Total Synthesis

Indole and isoquinoline nuclei bearing homoallylic amine cores are abundant in several prominent alkaloids, including strychnine. A recent study by Snaddon et al. reports a modular, cooperative catalysis platform to access linear and branched homoallylic amines, thereby streamlining enantioselective access to stereochemically complex Strychnos and Chelidonium alkaloids. Indole and isoquinoline nuclei bearing homoallylic amine cores are abundant in several prominent alkaloids, including strychnine. A recent study by Snaddon et al. reports a modular, cooperative catalysis platform to access linear and branched homoallylic amines, thereby streamlining enantioselective access to stereochemically complex Strychnos and Chelidonium alkaloids.