Correlation between environmental endocrine disruptors and onset of precocious puberty in children

Environmental endocrine disruptors are pollutants of many chemical classes,which are ubiquitous and persistent in the environment and can exert adverse effects on the endocrine system. Environmental endocrine disruptors are easily absorbed by the body, but not excreted. They are synergistic and hereditary. Therefore,environmental endocrine disruptors will severely destroy public health. Environmental endocrine disruptors, bringing about changes in morphology and function of the hypothalamus-pituitary-gonadal axis, interfering with the metabolism and transportation of estrogen, improve estrogen levels. They can activate estrogen receptor and enhance its sensitivity. By these means, environmental endocrine disruptors lead to early puberty development. Key words: Endocrine disruptors;  Puberty;  Precocious