IgE and Non-IgE mediate the activation of human mast cells

Mast cells are crucial effector cells in allergic reactions, where IgE is the most notably mechanism to trigger their degranulation and release large amounts of allergic mediators.However, IgE is not the only way to stimulate these cells to degranulate.There is a lot of stimuli, such as complement, neuropeptides, cytokines and other inflammatory products, which can directly trigger mast cell degranulation, and cause selective release of mediators.These mediators are closely related to many allergic and inflammatory diseases.The paper will focus on the activation of non-IgE stimulated human mast cells, and describe the allergic and inflammatory diseases briefly, and provide the theoretical basis for clinical detection, diagnosis and treatment. Key words: IgE; Mast cell; Allergic disease