上睑下垂
邻苯二甲酸盐
化学
脾脏
番茄红素
半胱氨酸蛋白酶1
生物化学
药理学
细胞凋亡
生物
程序性细胞死亡
免疫学
有机化学
类胡萝卜素
作者
Xueyan Dai,Xiaowei Li,Shi‐Yong Zhu,Muzi Li,Yi Zhao,Milton Talukder,Yanhua Li,Jinlong Li
标识
DOI:10.1021/acs.jafc.0c06534
摘要
Lycopene (Lyc) as a natural antioxidant has attracted widespread attention. Di(2-ethylhexyl) phthalate (DEHP) can cause serious spleen injury in animals via the environment and food chain. For investigation of whether Lyc could alleviate DEHP-exerted pyroptosis in spleen through inhibiting the Caspase-1/NLRP3 pathway activation, 140 male mice were randomly divided into 7 groups: control group, vehicle control group, Lyc group (5 mg/kg BW/day), DEHP-exposed group (500 or 1000 mg/kg BW/day, respectively), and DEHP + Lyc groups by daily administration for 28 days. Pathological results showed that the supplementation of Lyc alleviated DEHP-induced inflammatory infiltration. Moreover, the addition of Lyc inhibited DEHP-induced Caspase-1, NLRP3, ASC, NF-κB, IL-1β, and IL-18 overexpression and GSDMD down-expression. These results indicate that Lyc could inhibit DEHP-induced Caspase-1-dependent pyroptosis and the inflammatory response. Taken together, the study provided new evidence that Lyc may be a strategy to mitigate spleen injury induced by DEHP.
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