聚酮
酶
生物合成
生物化学
功能(生物学)
生物
化学
立体化学
计算生物学
遗传学
作者
Binbin Wang,Jianhe Wei,Zhenqiao Song,Zhihui Gao
出处
期刊:PubMed
[National Institutes of Health]
日期:2018-07-01
卷期号:43 (13): 2639-2647
标识
DOI:10.19540/j.cnki.cjcmm.20180514.003
摘要
Polyketides are a large class of natural products with notable structural diversity and different biological activities. They have essential pharmacological value for human health. In plants, the enzymes responsible for the formation of phenolic metabolites backbone structures are collectively known as type Ⅲ polyketide synthases (PKSs), which are the key enzymes for the polyketides biosynthesis. The PKSs catalyze a series of condensation reactions of two-carbon acetate units with an acyl starter. A brief overview of this group of enzymes, including their reaction mechanisms, function modification, expression regulation, molecular evolution, and recent interesting findings are presented here.
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