炎症
多囊卵巢
卵巢早衰
毛囊
氧化应激
褪黑素
病态的
卵泡
卵泡发生
毛囊
医学
内分泌学
生物
内科学
卵巢
胚胎发生
细胞生物学
糖尿病
胰岛素抵抗
胚胎
作者
Ziwei Yang,Zi-Juan Tang,Xia Cao,Qi Xie,Chuan Hu,Zhisheng Zhong,Jun Tan,Yuehui Zheng
摘要
Chronic low‐grade inflammation is one cause of follicle development disturbance. Chronic inflammation exists in pathological conditions such as premature ovarian failure, physiological aging of the ovaries, and polycystic ovary syndrome. Inflammation of the whole body can affect oocytes via the follicle microenvironment, oxidative stress, and GM‐CSF. Many substances without toxic side‐effects extracted from natural organisms have gradually gained researchers’ attention. Recently, chitosan oligosaccharide, resveratrol, anthocyanin, and melatonin have been found to contribute to an improvement in inflammation. This review discusses the interrelationships between chronic low‐grade inflammation and follicle development, the underlying mechanisms, and methods that may improve follicle development by controlling the level of chronic low‐grade inflammation.
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