化学
二羟基化
全合成
甲烷氧化偶联
苯酚
立体化学
氧化磷酸化
戒指(化学)
对映选择合成
序列(生物学)
盐(化学)
组合化学
有机化学
催化作用
生物化学
作者
Chaoying Zheng,Tao Xie,Haibing He,Shuanhu Gao
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-01-05
卷期号:23 (2): 469-473
被引量:5
标识
DOI:10.1021/acs.orglett.0c03990
摘要
A new approach was developed to achieve the asymmetric total synthesis of (+)-PD-116740, an angucyclinone from the actinomycete isolate (WP 4669). A sequence of asymmetric dihydroxylation followed by oxidative cyclization was applied to stereoselectively construct the core trans-9,10-dihydrophenanthrene-9,10-diol B–C–D ring. A new Cu salt Cu(OH)OTf·NMI2 was found to be the best oxidant to induce the oxidative coupling and phenol oxidation.
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