Multifunctional composite electrospinning fiber membranes promote neurovascular-network regeneration for diabetic wound repair

The healing of diabetic wounds remains a formidable challenge due to local vascular impairment, peripheral neuropathy, and bacterial infection. With the escalating global prevalence of diabetes, the management of diabetic wound healing has garnered increasing clinical attention; however, existing wound dressings demonstrate limited efficacy in treating diabetic neurovascular lesions. In this context, we developed novel wound dressing for diabetic wounds by integrating electrospinning with vacuum-assisted deposition. Bacterial cellulose (BC) was loaded within the polyacrylonitrile (PAN) electrospinning fibers to construct porous reticular architecture, which significantly enhanced both the mechanical strength and hydrophilicity of the composite fibers. Furthermore, the electrospinning fibers were loaded with berberine, a therapeutic agent that confers antibacterial, antioxidant, and anti-aging properties, while simultaneously promoting collagen deposition and the regeneration of neurovascular networks. In the in vivo experiments, the composite fibers ameliorated the pathological microenvironment of diabetic wounds by promoting the expression of anti‑inflammatory factors and inhibiting the production of pro‑inflammatory factors. Collectively, this study presents a promising strategy for neurovascular regeneration in diabetic wound healing.