Rationale: As a classic prescription for treating knee osteoarthritis (KOA), Du-Huo-Ji-Sheng-Decoction (DHJSD) has been widely recognized for its clinical efficacy.The purpose of this systematic review and m e t a -a n a l y s i s i s t o e v a l u a t e t h e effectiveness and safety of DHJSD in the treatment of KOA.