多重耐药
抗生素耐药性
抗菌剂
大流行
抗药性
重症监护医学
抗生素
生物
医学
生物技术
微生物学
2019年冠状病毒病(COVID-19)
传染病(医学专业)
疾病
病理
作者
Alessia Catalano,Domenico Iacopetta,Jessica Ceramella,Domenica Scumaci,Federica Giuzio,Carmela Saturnino,Stefano Aquaro,Camillo Rosano,Maria Stefania Sinicropi
出处
期刊:Molecules
[MDPI AG]
日期:2022-01-18
卷期号:27 (3): 616-616
被引量:150
标识
DOI:10.3390/molecules27030616
摘要
Multidrug resistance is a leading concern in public health. It describes a complex phenotype whose predominant feature is resistance to a wide range of structurally unrelated cytotoxic compounds, many of which are anticancer agents. Multidrug resistance may be also related to antimicrobial drugs, and is known to be one of the most serious global public health threats of this century. Indeed, this phenomenon has increased both mortality and morbidity as a consequence of treatment failures and its incidence in healthcare costs. The large amounts of antibiotics used in human therapies, as well as for farm animals and even for fishes in aquaculture, resulted in the selection of pathogenic bacteria resistant to multiple drugs. It is not negligible that the ongoing COVID-19 pandemic may further contribute to antimicrobial resistance. In this paper, multidrug resistance and antimicrobial resistance are underlined, focusing on the therapeutic options to overcome these obstacles in drug treatments. Lastly, some recent studies on nanodrug delivery systems have been reviewed since they may represent a significant approach for overcoming resistance.
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