医学
放射治疗
疾病
化疗
淋巴瘤
霍奇金淋巴瘤
免疫疗法
经典霍奇金淋巴瘤
肿瘤科
内科学
癌症
作者
Pauline Brice,É. de Kerviler,Jonathan W. Friedberg
出处
期刊:The Lancet
[Elsevier]
日期:2021-10-01
卷期号:398 (10310): 1518-1527
被引量:51
标识
DOI:10.1016/s0140-6736(20)32207-8
摘要
Classical Hodgkin lymphoma is one of the more frequent lymphomas and is generally considered a highly curable disease with standard first-line chemotherapy and radiotherapy in some cases. Despite these outstanding results, major problems remain unresolved. First, there are still patients who will not be cured with front-line regimens and, second, many patients who are cured of classical Hodgkin lymphoma continue to die prematurely due to the late toxic effects of their therapy. Because the median age of patients with classical Hodgkin lymphoma is in the mid-30s, the disease's impact on the number of years lost from productive life is remarkable. In recent years, the gold standard of chemotherapy (often combined with radiotherapy) has changed, with the approval of immunotherapy mostly in relapse settings.
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