神经退行性变
生物标志物
疾病
医学
神经学
正电子发射断层摄影术
诊断生物标志物
阿尔茨海默病
神经影像学
神经科学
重症监护医学
脑脊液
诊断试验
病理
心理学
诊断准确性
内科学
儿科
生物
生物化学
作者
Shan Huang,Yanjiang Wang,Junhong Guo
标识
DOI:10.1007/s12264-022-00836-7
摘要
Since the establishment of the biomarker-based A-T-N (Amyloid/Tau/Neurodegeneration) framework in Alzheimer's disease (AD), the diagnosis of AD has become more precise, and cerebrospinal fluid tests and positron emission tomography examinations based on this framework have become widely accepted. However, the A-T-N framework does not encompass the whole spectrum of AD pathologies, and problems with invasiveness and high cost limit the application of the above diagnostic methods aimed at the central nervous system. Therefore, we suggest the addition of an "X" to the A-T-N framework and a focus on peripheral biomarkers in the diagnosis of AD. In this review, we retrospectively describe the recent progress in biomarkers based on the A-T-N-X framework, analyze the problems, and present our perspectives on the diagnosis of AD.
科研通智能强力驱动
Strongly Powered by AbleSci AI