Stereodivergent access to rocaglaol enabled by dual catalytic asymmetric allylation

In a recent issue of Chem , Liu and Feng et al. report a stereodivergent allylation of benzofuran-3( 2H )-one catalyzed by two chiral metal catalysts, a phosphoramidite-Ir complex and an N,N′ -dioxide-ligated Lewis acid, and its application to the selective total synthesis of eight stereoisomers of rocaglaol, one of the flavagline-family bioactive molecules. In a recent issue of Chem , Liu and Feng et al. report a stereodivergent allylation of benzofuran-3( 2H )-one catalyzed by two chiral metal catalysts, a phosphoramidite-Ir complex and an N,N′ -dioxide-ligated Lewis acid, and its application to the selective total synthesis of eight stereoisomers of rocaglaol, one of the flavagline-family bioactive molecules.