Wnt信号通路
癌症研究
结直肠癌
脱甲基剂
雌激素受体
DNA甲基化
转移
核受体
生物
上皮-间质转换
连环素
癌症
乳腺癌
信号转导
内科学
转录因子
医学
基因表达
细胞生物学
遗传学
基因
作者
Xingli Guo,Yue Liu,Min Li,Ang Dai,Junying Sun,Lei Fang,Hai Zhao,Qing Sun
出处
期刊:Carcinogenesis
[Oxford University Press]
日期:2022-06-21
卷期号:43 (9): 865-873
被引量:3
标识
DOI:10.1093/carcin/bgac054
摘要
Abstract Colorectal cancer (CRC) is the predominant cause of cancer-related death worldwide, because of the lack of effective therapeutic targets. Estrogen-related receptor gamma (ESRRG), which belongs to the family of nuclear receptors, functions as an important element regulating gene transcription. In our report, we identified ESRRG as a potential tumor suppressor. The decreased level of ESRRG was initially observed in CRC and was highly associated with a poor prognosis. ESRRG overexpression abrogated cell growth and metastasis in vitro and in vivo. Mechanistically, ESRRG repressed the epithelial-to-mesenchymal transition process and antagonized Wnt signaling by regulating β-catenin degradation. In addition, significant ESRRG hypermethylation was found in CRC and inversely correlated with its expression. Consistently, the expression of ESRRG was induced after treatment with DNA demethylating agent 5-aza-2ʹ-deoxycytidine. Taken together, these findings define a tumor-suppressive role of ESRRG in CRC, providing a potential novel therapeutic approach for this cancer.
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