生物相容性
细菌纤维素
生物膜
伤口愈合
活性氧
抗菌活性
葡萄糖氧化酶
细菌
材料科学
聚丙烯
生物污染
脚手架
壳聚糖
化学
纤维素
生物化学
生物传感器
有机化学
生物医学工程
医学
生物
膜
免疫学
遗传学
作者
Shumin Zhang,Zhengming Yang,Jican Hao,Fang Ding,Zhiguang Li,Xiaofeng Ren
标识
DOI:10.1016/j.cej.2021.134309
摘要
Reactive oxygen species (ROS) have been demonstrated to be an effective substance for combating bacterial infections. Inspired by the biocatalytic ability of nanozymes in regulating ROS levels, nanozyme-based wound dressing with intelligent ROS mediating ability is a promising therapeutic strategy for combating bacterial infections in wounds. Herein, a hollow mesoporous nanocatalyst ([email protected]) assembled with glucose oxidase (GOx) with multienzyme-mimicking activity was developed. The designed [email protected] can effectively catalyze physiological levels of glucose into highly reactive hydrogen radicals via a self-triggered cascade reaction, which resulted in remarkable antibacterial ability. To address the limits of nanozymes in wound treating, a novel antibacterial wound dressing was fabricated by assembling the prepared nanocatalyst on the biosynthesized bacterial cellulose (BC) enveloped polypropylene (PP) composites. The BC layer on PP nonwoven fabrics was produced with PP serving as the scaffold in the culture medium for BC formation, which endowed the prepared dressing outstanding moisture retention ability. The nanozyme-based wound dressing possesses outstanding breathability, remarkable biocompatibility and bacteria inactivation ability, as well as could significantly inhibit the biofilm formation. Further, in vivo study demonstrated it can effectively promote wound healing caused by bacterial infections, which has a great potential for ROS mediated biocatalytic therapy.
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