镧系元素
纳米团簇
犬尿氨酸
尿
发光
材料科学
检出限
生物标志物
纳米技术
化学
色谱法
色氨酸
光电子学
有机化学
生物化学
氨基酸
离子
作者
Yun Chen,Xiaobo Yu,Yefei Jiang,Liu Min,Zhao Chen,Liwen Ding,Bo Li,Chenghui Zeng
标识
DOI:10.1016/j.saa.2021.120782
摘要
The level of L-kynurenine (L-kyn) can reflect the health state of human body, and the determination of L-kyn can be used for the medical diagnosis of several cancers and neurological diseases. In this work, a series of air-, water-, and thermo-stable dinuclear lanthanide nanoclusters [Ln2(2,5-DFBA)6(phen)2] (Tb 1, Eu 2, Gd 3, 2,5-DFBA = 2,5-difluorobenzoic acid, phen = 1,10-phenanthroline) are obtained by a facial method. 1 and 2 show very high luminescence quantum yields (QYs) of 71.7% and 81.8%, respectively. Interestingly, investigation reveals that 1 is a quick, highly sensitive and selective sensor for L-kyn in real samples of urine and serum. Furthermore, transmission electron microscope (TEM) results reveal that nanocluster 1 is stable in solution and can be uniform distributed on the base, suggesting it can be deposited on various supports to fabricate sensing devices. Thus, 1 is fabricated into a sensitive test paper for the eye-readable detection of L-kyn in real samples of human urine and serum. The limit of detection (LOD) as low as 0.3 μM, which is enough to rapidly determine L-kyn in human body liquor (usually 5 μM in healthy human body).
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