恶病质
塞德
全身炎症
医学
炎症
内科学
内分泌学
有氧运动
体育锻炼
癌症
作者
Nicole Wood,Jacob Garritson,Alissa Mathias,James M. Haughian,Reid Hayward
出处
期刊:Anticancer Research
[Anticancer Research USA Inc.]
日期:2021-12-29
卷期号:42 (1): 397-405
被引量:2
标识
DOI:10.21873/anticanres.15498
摘要
Cancer cachexia encompasses several deleterious physiological alterations associated with functional impairments, poor quality of life, and increased mortality. The aim of this study was to examine the effects of chronic moderate intensity exercise training on markers of cachexia.Balb/c mice were randomly assigned to sedentary (SED) or exercise (EX) groups and EX mice were further randomly assigned to one of three exercise modalities (aerobic, resistance, combined).Cachexia was induced in SED animals inoculated with C26 cells, as evidenced by significant changes in numerous markers. All cachexia-related perturbations were significantly attenuated in EX versus SED animals. Systemic inflammation was significantly decreased in all EX groups, as evident by a normalization of spleen mass and plasma IL-6.Multiple moderate intensity exercise modalities can provide significant benefits in cachectic mice, and this may be due, at least in part, to decreased systemic inflammation.
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