橙皮苷
槲皮素
细胞凋亡
化学
药理学
炎症
结肠炎
肿瘤坏死因子α
半胱氨酸蛋白酶3
热休克蛋白
抗氧化剂
医学
免疫学
生物化学
病理
程序性细胞死亡
基因
替代医学
作者
Berrak Güven,Murat Çan,Özcan Pişkin,Bengü Gülhan Aydın,Kemal Karakaya,Özlem Elmas,Bilgehan Açıkgöz
标识
DOI:10.1016/j.yrtph.2019.03.006
摘要
Radiation induced colitis is one the most common clinical issue for patients receiving radiotherapy. For this reason, we aimed to investigate the effect of antioxidant-effective flavonoids hesperidin and quercetin on the intestinal damage induced by radiation in this study. TNF-alpha, interleukin-10 (IL-10), heat shock protein 70 (HSP 70) and caspase 3, 8, 9 markers of apoptotic pathways were measured in the colon tissues of irradiated acute intestinal damage by enzyme-linked immunosorbent assay (ELISA). Irradiation of rats caused a significance increase of TNF-alpha, caspase 3/8/9 and decrease of IL-10 concentrations. Hesperidin and quercetin treatment resulted in decreased levels of TNF-alpha and increased levels of IL-10. Quercetin significantly decreased caspase 3/8/9 levels. Hesperidin produced a decreased of caspase 3/8/9 levels compared with irradiation group but this was statistically not significant. Only significant alteration of HSP 70 were seen in hesperidin treated rats. Further studies are needed to elucidate the mechanism by which flavonoids induced signaling provides protection against apoptosis and inflammation.
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