ATF3
转录因子
激活转录因子
细胞生物学
激活剂(遗传学)
生物
抄写(语言学)
DNA损伤
基因
癌症研究
发起人
基因表达
DNA
遗传学
语言学
哲学
作者
M. Rohini,A. Haritha Menon,N. Selvamurugan
标识
DOI:10.1016/j.ijbiomac.2018.08.107
摘要
Activating transcription factor 3 (ATF3) is a stress-responsive factor that belongs to the activator protein 1 (AP-1) family of transcription factors. ATF3 expression is stimulated by various factors such as hypoxia, cytokines, and chemotherapeutic and DNA damaging agents. Upon stimulation, ATF3 can form homodimers or heterodimers with other members of the AP-1 family to repress or activate transcription. Under physiological conditions, ATF3 expression is transient and plays a pivotal role in controlling the expression of cell-cycle regulators and tumor suppressor, DNA repair, and apoptosis genes. However, under pathological conditions such as those during breast cancer, a sustained and prolonged expression of ATF3 has been observed. In this review, the structure and function of ATF3, its posttranslational modifications (PTM), and its interacting proteins are discussed with a special emphasis on breast cancer metastasis.
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