Response by Fan et al to Letter Regarding Article, “Dectin-1 Contributes to Myocardial Ischemia/Reperfusion Injury by Regulating Macrophage Polarization and Neutrophil Infiltration”

we believe that studying the role of Dectin-1 in heart rhythm or cardiac conduction is important and potentially interesting, this is beyond the scope of the current study. 4We will explore its specific functions in future studies.However, Dectin-1 was found to be dispensable for the development of atherosclerosis in one study, 5 suggesting that Dectin-1 may mediate cardiac ischemia/reperfusion injury, in particular.In summary, we completely agree that understanding the specific function of macrophage subsets during cardiac injury, and the steady state, as well, will provide novel insights into our understanding of this pathophysiological process and our search for potential therapeutic strategies.