Predictors and consequences of postdischarge gastrointestinal bleeding after percutaneous coronary intervention

Summary Aim To evaluate the incidence, predictors, and outcomes of postdischarge gastrointestinal bleeding ( GIB ) in patients underwent percutaneous coronary intervention ( PCI ) in a 2‐year follow‐up study. Methods and Results All consecutive patients who underwent PCI throughout 2013 were enrolled. Multivariable cox proportional hazards regression were used to identify predictors of postdischarge GIB and 2‐year major adverse cardiovascular and cerebrovascular events ( MACCE ). Among 10 637 enrolled patients, postdischarge GIB events occurred in 123 (1.1%) patients at a median time of 329 days (interquartile range: 191‐504 days). Predictor of postdischarge GIB included renal dysfunction and use of ticagrelor. There was no significant association between postdischarge GIB and MACCE (7.3% vs 12.0%, P = .092). Among whole population, 310 (2.91%) patients had dual antiplatelet therapy ( DAPT ) cessation. DAPT cessation was strongly associated with 2‐year mortality (21.6% vs 0.4%, P < .001). Conclusion In this large cohort of real‐world patients after PCI , postdischarge GIB was not significantly associated with MACCE up to 2 years of follow‐up but lead to an increase in DAPT cessation, and DAPT cessation was strongly associated with 2‐year mortality.