吞噬作用
吞噬体
生物
细胞生物学
免疫系统
平衡
免疫学
作者
Charlene E. Lancaster,Cheuk Y. Ho,Victoria E. B. Hipolito,Roberto J. Botelho,Mauricio R. Terebiznik
标识
DOI:10.1139/bcb-2018-0008
摘要
Phagocytosis is an evolutionarily conserved process. In Protozoa, phagocytosis fulfills a feeding mechanism, while in Metazoa, phagocytosis diversified to play multiple organismal roles, including immune defence, tissue homeostasis, and remodeling. Accordingly, phagocytes display a high level of plasticity in their capacity to recognize, engulf, and process targets that differ in composition and morphology. Here, we review how phagocytosis adapts to its multiple roles and discuss in particular the effect of target morphology in phagocytic uptake and phagosome maturation.
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