High NUP43 expression might independently predict poor overall survival in luminal A and in HER2+ breast cancer

Aim: To explore the independent prognostic value of NUP43 in terms of overall survival (OS) and the mechanisms of its dysregulation in breast cancer. Patients & methods: Bioinformatic analysis was performed by using data from The Cancer Genome Atlas-breast invasive carcinoma. Results: High NUP43 expression was an independent prognostic factor of poor OS in luminal A subtype (HR: 2.400; 95% CI: 1.070–5.379; p = 0.034) and in HER2+ subtype (HR: 10.578; 95% CI: 1.850–60.473; p = 0.008). NUP43 DNA amplification was associated with elevated NUP43 expression, while DNA deletion was associated with decreased NUP43 transcription. Conclusion: NUP43 upregulation was related to DNA amplification and might independently predict poor OS in luminal A and in HER2+ breast tumors.