Silk fibroin is a natural biomaterial protein due to its excellent biocompatibility, biodegradability, mechanical property and processibility. The properties of biomaterial scaffolds are quite strict and complex for its practical applica tion in tissue engineering. Recently, many researches on structure biocompatibility and cell biocompatibility of silk fibro in have been conducted. The results showed good biocompatibility of fibroin, which is important for promoting the appli cation of fibroin in tissue engineering.