Objective To summarize the clinical manifestations,diagnosis and therapy of acute pulmonary embolism for improving our realization on it,and lowering the rate of missed diagnosis and misdiagnosis.Methods Retrospectively analyzed the clinical manifestation,diagnosis and treatment of 21 cases with pulmonary embolism from July 2007 to January 2010 in my hospital.Results One case was diagnosed by clinical manifestations,20 cases were diagnosed by CTPA(computer tomography pulmonary arteriography,CTPA).Seven cases received thrombolysis and anticoagulant therapy,and 13 cases only received anticoagulant therapy.There was no significantly difference in the effective rate between the two methods.Conclusion The clinical manifestations of acute pulmonary embolism have no special.A negative D-dimer test result may strongly suggest that PE is absent.CTPA is preferred final diagnosis.Physicians should pay more attentions to PE in order to improve a diagnostic accuracy.The standard therapy may improve the prognosis significantly.