The effects of Hawthorn leaves flavonoids on insulin-like growth factor-1 expression in kidney of type II diabetic rats

Objective: To investigate the effects of Hawthorn leaves flavonoids on insulin-like growth factor-1(IGF-1) expression in kidney of type II diabetic rats,and to study the treatment effect of it on diabetic nephropathy.Methods: Induce type 2 diabetic rats by intravenous injection of STZ and high-fat and high-sugar feeding.To treat diabetic rats with high dose(200mg/kg) and low dose(50mg/kg) of Hawthorn leaves flavonoids separately.To detect the level of blood sugar,urine protein,blood urea nitrogen and creatinine after 12 weeks treatment.And detect the expression level of IGF-1 in kidney by immunohistochemistry.Results: Hawthorn leaves flavonoids can reduce the levels of blood sugar,urine protein,blood urea nitrogen and creatinine of diabetic rats(P0.01).Hawthorn leaves flavonoids can improve the functions of kidney of diabetic rats.After treatment,the expression of IGF-1 in kidney of diabetic rats significantly reduce(P0.01).Conclusion: Hawthorn leaves flavonoids have therapeutic effect on type II diabetic nephropathy by reducing the expression of IGF-1.