Traditional Chinese medicine(TCM) holds that many tumors in the advanced stage show the symptom of blood stasis,so blood circulation by removing blood stasis method becomes important treatment for advanced malignant tumors. Experiments in vivo and in vitro shows sappan wood antitumor effect and the research at home and abroad are introduced. Sappan wood and other promoting blood circulation to remove blood stasis mechanism of inhibiting tumor were analyzed to provide basis for clinical medicine for activating blood circulation antitumor.