Development and Properties of Temperature-sensitive Poly(N-isopropylacrylamide) Nanocapsules

Temperature-sensitive nanocapsules were prepared using SiO2 as template and N-isopropylacrylamide(NIPAm) as temperature-sensitive polymer,respectively.And the characterizations were investigated by TEM,FT-IR,TGR and UV techniques.Nanocapsules were applied to load of malachite green.The results indicated that NIPAm was grafted successfully onto the surface of SiO2.The nanocapsules were formed after removal of SiO2 by HF solutions.The nanocapsules have the ability of reversible temperature-sensitive with higher loading capability.Thus,the application of such temperature-sensitive nanocapsules might offer a potential technology for drug delivery.