Targeted Protection of Donor Graft Vasculature Using a Phosphodiesterase Inhibitor Increases Survival and Predictability of Autologous Fat Grafts

Fat graft vascularization is critically dependent on maintenance of the donor microvasculature. Sildenafil protects the donor microvasculature during transfer and revascularization, increasing long-term volume retention. These data demonstrate a rapidly translatable method of increasing predictability and durability of fat grafting in clinical practice.